Ethyl Lactate Synthesis by Lipase in Organic Media

Abstract

Abstract: Esterification of lactic acid and ethanol by lipase under double substrate inhibition was studied. The best solvent is tert-butyl alcohol and the best lipase is Novozym 435 (immobilized on a macroporous acrylic resin) for this reaction system. The optimization of reaction conditions was studied in detail. When the molar ratio of acid to alcohol is 1∶8, the temperature is 60 ℃, the concentration of acid and lipase is 0.3 mol/L and 45 g/mol, and the revolution is 200 r/min, a yield of 77% was reached. Novozym 435 has a high stability. A yield of 60% for ethyl lactate can be obtained with Novozym 435 even after it was used continuously six times.

Key words: lipase, lactic acid, ethanol, esterification, ethyl lactate, double substrates inhibition

ZHAO Tiantao1,2, GAO Jing2*, ZHANG Lijie1, QUAN Xuejun1. Ethyl Lactate Synthesis by Lipase in Organic Media[J]. Chinese Journal of Catalysis, 2006, 27(6): 537-540.

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https://www.cjcatal.com/EN/Y2006/V27/I6/537

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Ethyl Lactate Synthesis by Lipase in Organic Media

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