Chinese Journal of Catalysis ›› 2015, Vol. 36 ›› Issue (1): 40-47.DOI: 10.1016/S1872-2067(14)60164-9

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Pd-catalyzed intramolecular aminofluorination of allylic sulfamides

Jiashun Cheng, Pinhong Chen, Guosheng Liu   

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
  • Received:2014-05-19 Revised:2014-06-09 Online:2014-12-31 Published:2014-12-31
  • Supported by:

    This work was supported by the National Basic Research Program of China (973 program, 2011CB808700), the National Natural Science Foundation of China (21225210, 20923005 and 21121062), the Science and Technology Commission of Shanghai Municipality (11JC1415000), and the CAS/SAFEA International Partnership Program for Creative Research Teams.

Abstract:

A facile Pd-catalyzed intramolecular aminofluorination reaction of allylic sulfamides was developed that can be used to prepare fluorinated 1,3-diamine derivatives. Acetic acid was essential for regulation to give the major 6-endo cyclization products.

Key words: Palladium-catalyzed, Aminofluorination, Alkene, Fluorinated 1,3-diamine, 6-Endo cyclization