催化学报

催化学报 ›› 2011, Vol. 32 ›› Issue (12): 1850-1855.DOI: 10.1016/S1872-2067(10)60295-1

• 研究论文 • 上一篇    下一篇

Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions

Javad SAFARI1,*, Sayed Hossein BANITABA1, Shiva DEHGHAN KHALILI1,2   

  1. 1Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, Kashan, 87317-51167, Iran; 2Islamic Azad University Najafabad Branch, Najafabad, 85141-43131, Iran
  • 收稿日期:2011-06-14 修回日期:2011-10-12 出版日期:2011-12-21 发布日期:2015-04-23

Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions

Javad SAFARI1,*, Sayed Hossein BANITABA1, Shiva DEHGHAN KHALILI1,2   

  1. 1Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, Kashan, 87317-51167, Iran; 2Islamic Azad University Najafabad Branch, Najafabad, 85141-43131, Iran
  • Received:2011-06-14 Revised:2011-10-12 Online:2011-12-21 Published:2015-04-23

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摘要： A straightforward and general method has been developed for the synthesis of C5-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction.

关键词: cobalt nanoparticle, 1,4-dihydropyridine, four-component condensation, heterogeneou catalyst, magnetically separable catalyst

Abstract: A straightforward and general method has been developed for the synthesis of C5-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction.

Key words: cobalt nanoparticle, 1,4-dihydropyridine, four-component condensation, heterogeneou catalyst, magnetically separable catalyst