铑-ImiFerroPhos配合物对β-取代-α,β-不饱和磷酸酯的不对称氢化

doi:10.1016/S1872-2067(12)60742-6

催化学报 ›› 2014, Vol. 35 ›› Issue (2): 227-231.DOI: 10.1016/S1872-2067(12)60742-6

铑-ImiFerroPhos配合物对β-取代-α,β-不饱和磷酸酯的不对称氢化

段正超^a, 王联芝^a, 左晓宇^a, 胡向平^b, 郑卓^b

a 湖北民族学院化学与环境工程学院, 湖北恩施445000;
b 中国科学院大连化学物理研究所, 辽宁大连116023

收稿日期:2013-09-11 修回日期:2013-10-23 出版日期:2014-01-16 发布日期:2014-01-17
通讯作者: 段正超, 胡向平
基金资助:
国家自然科学基金（21262011）.

Rh-ImiFerroPhos complexes catalyzed asymmetric hydrogenation of β-substituted α,β-unsaturated phosphonates

Zhengchao Duan^a, Lianzhi Wang^a, Xiaoyu Zuo^a, Xiangping Hu^b, Zhuo Zheng^b

a School of Chemical and Enviromental Engineering, Hubei University for Nationalities, Enshi 445000, Hubei, China;
b Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China

Received:2013-09-11 Revised:2013-10-23 Online:2014-01-16 Published:2014-01-17
Contact: Zhengchao Duan, Xiangping Hu
Supported by:
This work was supported by the National Natural Science Foundation of China (21262011).

摘要/Abstract

摘要：

将手性二茂铁双膦配体ImiFerroPhos应用到β-取代-α，β-不饱和磷酸酯的不对称氢化反应中，在温和的反应条件下，以高收率及较高对映选择性合成了一系列β-取代的手性磷酸酯，最高获得了92%的ee值.

关键词: β-取代-α,β-不饱和磷酸酯, 不对称催化氢化, ImiFerroPhos配体, 铑(Ⅱ)配合物, 手性β-取代烷基磷酸酯

Abstract:

A series of chiral ferrocenyl diphosphine ligands (ImiFerroPhos ligands) has been applied to the hydrogenation of β-substituted α,β-unsaturated phosphonates to generate a range of optically active β-substituted alkylphosphonates in good yields with good enantioselectivity (up to 92% ee) under mild reaction conditions.

Key words: β-Substituted α,β-unsaturated phosphonate, Asymmetric catalytic hydrogenation, ImiFerroPhos ligands, Rhodium (Ⅱ) complex, Chiral β-substituted alkylphosphonate

段正超, 王联芝, 左晓宇, 胡向平, 郑卓. 铑-ImiFerroPhos配合物对β-取代-α,β-不饱和磷酸酯的不对称氢化[J]. 催化学报, 2014, 35(2): 227-231.

Zhengchao Duan, Lianzhi Wang, Xiaoyu Zuo, Xiangping Hu, Zhuo Zheng. Rh-ImiFerroPhos complexes catalyzed asymmetric hydrogenation of β-substituted α,β-unsaturated phosphonates[J]. Chinese Journal of Catalysis, 2014, 35(2): 227-231.

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铑-ImiFerroPhos配合物对β-取代-α,β-不饱和磷酸酯的不对称氢化

Rh-ImiFerroPhos complexes catalyzed asymmetric hydrogenation of β-substituted α,β-unsaturated phosphonates

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