新型碱性离子液体催化剂高效催化合成吡喃酮[2,3-d]嘧啶酮和[2,3-d]嘧啶衍生物

doi:10.1016/S1872-2067(17)62827-4

催化学报 ›› 2017, Vol. 38 ›› Issue (7): 1245-1251.DOI: 10.1016/S1872-2067(17)62827-4

新型碱性离子液体催化剂高效催化合成吡喃酮[2,3-d]嘧啶酮和[2,3-d]嘧啶衍生物

Omid Goli Jolodar, Farhad Shirini, Mohadeseh Seddighi

桂兰大学理学院化学系, 雷什特 41335, 伊朗

出版日期:2017-07-18 发布日期:2017-06-27
通讯作者: Farhad Shirini

Efficient synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives in presence of novel basic ionic liquid catalyst

Omid Goli Jolodar, Farhad Shirini, Mohadeseh Seddighi

Department of Chemistry, Faculty of Sciences, University of Guilan, Rasht 41335, Iran

Online:2017-07-18 Published:2017-06-27
Contact: 10.1016/S1872-2067(17)62827-4

摘要/Abstract

摘要：

制备了碱性离子液体1，1'-（丁烷-1，4-二基）双（1，4-二氮杂二环[2.2.2]辛烷-1-ium）羟化物，并采用红外光谱、¹H核磁共振谱和pH值分析对其进行了表征.然后将它用于室温研磨条件下高效催化合成吡喃酮[2，3-d]嘧啶酮和[2，3-d]嘧啶.该法步骤简单，反应时间短，产物收率高，无需柱色谱分离，原料易得，且可回收利用.

关键词: 碱性催化剂, 多组分反应, 嘧啶衍生物, 研磨

Abstract:

A basic ionic liquid, namely 1,1'-(butane-1,4-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) hydrox-ide, was prepared and characterized using Fourier-transform infrared spectroscopy, ¹H nuclear magnetic resonance spectroscopy, and pH measurements. The ionic liquid was used for efficient promotion of the synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives at room temperature under grinding conditions. A simple procedure, short reaction time, high yields, non-column chromatographic separation, commercial availability of the starting materials, and recyclability of the catalyst are attractive features of this process.

Key words: Basic catalyst, Multicomponent reaction, Pyrimidine derivative, Grinding

Omid Goli Jolodar, Farhad Shirini, Mohadeseh Seddighi. 新型碱性离子液体催化剂高效催化合成吡喃酮[2,3-d]嘧啶酮和[2,3-d]嘧啶衍生物[J]. 催化学报, 2017, 38(7): 1245-1251.

Omid Goli Jolodar, Farhad Shirini, Mohadeseh Seddighi. Efficient synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives in presence of novel basic ionic liquid catalyst[J]. Chinese Journal of Catalysis, 2017, 38(7): 1245-1251.

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新型碱性离子液体催化剂高效催化合成吡喃酮[2,3-d]嘧啶酮和[2,3-d]嘧啶衍生物

Efficient synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives in presence of novel basic ionic liquid catalyst

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