生物制造不同立体构型2,3-丁二醇: 合成机理与实现方法

doi:10.3724/SP.J.1088.2013.20737

催化学报 ›› 2013, Vol. 34 ›› Issue (2): 351-360.DOI: 10.3724/SP.J.1088.2013.20737

生物制造不同立体构型2,3-丁二醇: 合成机理与实现方法

沈梦秋1, 纪晓俊1,a, 聂志奎1, 夏志芳1, 杨晗1, 黄和1,2,b

1南京工业大学生物与制药工程学院, 江苏南京 211816; 2南京工业大学材料化学工程国家重点实验室, 江苏南京 210009

收稿日期:2012-08-10 修回日期:2012-10-18 出版日期:2013-02-05 发布日期:2013-02-05

Biotechnological production of 2,3-butanediol stereoisomers: synthetic mechanism and realized methods

SHEN Mengqiu1, JI Xiaojun1,a, NIE Zhikui1, XIA Zhifang1, YANG Han1, HUANG He1,2,b

1College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China; 2State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, Jiangsu, China

Received:2012-08-10 Revised:2012-10-18 Online:2013-02-05 Published:2013-02-05

摘要/Abstract

摘要： 总结了不同 2,3-丁二醇立体异构体的生物合成机制, 以及有利于这些立体异构体高效合成的一些策略, 包括构建全细胞催化剂及利用合成生物学技术重建代谢途径等先进方法; 同时指出, 未来的研究重点是进一步利用合成生物学的方法, 以提高不同立体构型 2,3-丁二醇的生物合成能力, 并建立这些异构体高效可行的分离方法.

关键词: 2,3-丁二醇, 立体构型, 合成机理, 全细胞催化, 合成生物学

Abstract: 2,3-Butanediol, an important fine chemical, has been widely used in many areas. Containing two chiral centers, the molecule of 2,3-butanediol contains three stereoisomers, namely (S,S)-, (R,R)-, and meso-2,3-butanediol, which are especially crucial in providing chiral groups for the synthesis of fine chemicals and high-value pharmaceuticals. In this review, the synthetic mechanisms of different 2,3-butanediol stereoisomers are firstly revisited. Some strategies for efficient and economical pure 2,3-butanediol stereoisomers production, including constructing whole cell biocatalysts and constructing metabolic pathways using the emerging synthetic biology methods, are summarized. It is also pointed out that the focus of future research should be placed on improving the biosynthetic capability of different stereo- isomers using the synthetic biology methods, and establishing efficient downstream separation methods for economical 2,3-butanediol stereoisomers recovering process.

Key words: 2,3-butanediol, stereoisomer, synthetic mechanism, whole cell catalysis, synthetic biology

沈梦秋, 纪晓俊, 聂志奎, 夏志芳, 杨晗, 黄和. 生物制造不同立体构型2,3-丁二醇: 合成机理与实现方法[J]. 催化学报, 2013, 34(2): 351-360.

SHEN Meng-Qiu, JI Xiao-Jun, NIE Zhi-Kui, XIA Zhi-Fang, YANG Han, HUANG He. Biotechnological production of 2,3-butanediol stereoisomers: synthetic mechanism and realized methods[J]. Chinese Journal of Catalysis, 2013, 34(2): 351-360.

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生物制造不同立体构型2,3-丁二醇: 合成机理与实现方法

Biotechnological production of 2,3-butanediol stereoisomers: synthetic mechanism and realized methods

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