Titanium Dioxide Nanoparticles Catalyzed Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives

doi:10.1016/S1872-2067(11)60435-X

Chinese Journal of Catalysis ›› 2012, Vol. 33 ›› Issue (9): 1517-1522.DOI: 10.1016/S1872-2067(11)60435-X

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Titanium Dioxide Nanoparticles Catalyzed Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives

Mahmood TAJBAKHSH1,*, Ehsan ALAEE2, Heshmatollah ALINEZHAD1, Mohammad KHANIAN1, Fatemeh JAHANI1, Samad KHAKSAR3, Parizad REZAEE1, Mahgol TAJBAKHSH1

1Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47415, Iran; 2Gorgan Medical University, Gorgan, Iran; 3Chemistry Department, Islamic Azad University, Ayatollah Amoli Branch, Amol P.O. Box 678, Iran

Received:2012-03-25 Revised:2012-06-14 Online:2012-09-11 Published:2012-09-11

Abstract

Abstract: 1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst. The present methodology offers several advantages such as excellent yields, short reaction times (30–120 min), environmentally benign, and mild reaction conditions. The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse.

Key words: titanium dioxide nanoparticles, Hantzsch reaction, 1,4-dihydropyridine, polyhydroquinoline

Mahmood TAJBAKHSH, Ehsan ALAEE, Heshmatollah ALINEZHAD, Mohammad KHANIAN, Fatemeh JAHANI, Samad KHAKSAR, Parizad REZAEE, Mahgol TAJBAKHSH. Titanium Dioxide Nanoparticles Catalyzed Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives[J]. Chinese Journal of Catalysis, 2012, 33(9): 1517-1522.

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Titanium Dioxide Nanoparticles Catalyzed Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives

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