催化学报

催化学报 ›› 2012, Vol. 33 ›› Issue (9): 1517-1522.DOI: 10.1016/S1872-2067(11)60435-X

• 研究论文 • 上一篇    下一篇

Titanium Dioxide Nanoparticles Catalyzed Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives

Mahmood TAJBAKHSH1,*, Ehsan ALAEE2, Heshmatollah ALINEZHAD1, Mohammad KHANIAN1, Fatemeh JAHANI1, Samad KHAKSAR3, Parizad REZAEE1, Mahgol TAJBAKHSH1   

  1. 1Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47415, Iran; 2Gorgan Medical University, Gorgan, Iran; 3Chemistry Department, Islamic Azad University, Ayatollah Amoli Branch, Amol P.O. Box 678, Iran
  • 收稿日期:2012-03-25 修回日期:2012-06-14 出版日期:2012-09-11 发布日期:2012-09-11

Titanium Dioxide Nanoparticles Catalyzed Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives

Mahmood TAJBAKHSH1,*, Ehsan ALAEE2, Heshmatollah ALINEZHAD1, Mohammad KHANIAN1, Fatemeh JAHANI1, Samad KHAKSAR3, Parizad REZAEE1, Mahgol TAJBAKHSH1   

  1. 1Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47415, Iran; 2Gorgan Medical University, Gorgan, Iran; 3Chemistry Department, Islamic Azad University, Ayatollah Amoli Branch, Amol P.O. Box 678, Iran
  • Received:2012-03-25 Revised:2012-06-14 Online:2012-09-11 Published:2012-09-11

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摘要： 1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst. The present methodology offers several advantages such as excellent yields, short reaction times (30–120 min), environmentally benign, and mild reaction conditions. The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse.

关键词: titanium dioxide nanoparticles, Hantzsch reaction, 1,4-dihydropyridine, polyhydroquinoline

Abstract: 1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst. The present methodology offers several advantages such as excellent yields, short reaction times (30–120 min), environmentally benign, and mild reaction conditions. The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse.

Key words: titanium dioxide nanoparticles, Hantzsch reaction, 1,4-dihydropyridine, polyhydroquinoline