催化学报

催化学报 ›› 2010, Vol. 31 ›› Issue (11): 1316-1320.DOI: 10.1016/S1872-2067(10)60119-2

• 研究快讯 • 上一篇    下一篇

醋酸钯催化甲苯中无配体的 Suzuki 反应

刘宁, 刘春, 金子林   

  1. 大连理工大学精细化工国家重点实验室, 辽宁大连 116012
  • 收稿日期:2010-07-29 出版日期:2010-11-12 发布日期:2014-03-28

An Efficient Protocol for a Pd(OAc)2-Catalyzed Ligand-Free Suzuki Reaction in Toluene

LIU Ning, LIU Chun*, JIN Zilin   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, Liaoning, China
  • Received:2010-07-29 Online:2010-11-12 Published:2014-03-28

PDF

1261

被引次数

17

摘要： 报道了一种甲苯中醋酸钯催化无配体的 Suzuki 反应体系. 以 K3PO4·7H2O 为碱, 在该体系中可高效进行芳基溴代物和芳基硼酸的 Suzuki 反应, 且具有反应条件温和、无需惰性气体保护等特点. 在 n(ArBr) = 0.5 mmol, n(ArB(OH)2) = 0.75 mmol, x(Pd(OAc)2) = 1 mol%, n(K3PO4·7H2O) = 1.0 mmol, v(甲苯) = 2 ml 的优化条件下, 4-溴硝基苯和苯硼酸在 75 °C 反应 5 min, 分离收率即达 99%, TOF 高达 1 188 h?1.

关键词: Suzuki 反应, 芳基硼酸, 芳基卤代物, 钯, 无配体, 甲苯

Abstract: An efficient protocol for a Pd(OAc)2-catalyzed ligand-free Suzuki reaction of aryl bromides with arylboronic acids in the presence of K3PO4·7H2O in toluene under mild and aerobic conditions afforded cross-coupling products in good to excellent yields. Under the optimized reaction conditions (i.e., 0.5 mmol ArBr, 0.75 mmol ArB(OH)2, 1 mol% Pd(OAc)2, 1.0 mmol K3PO4·7H2O, 2 ml toluene), the Suzuki reaction between 4-nitrobromobenzene and phenylboronic acid afforded a 99% isolated yield in 5 min at 75 °C and a TOF of up to 1 188 h-1.

Key words: Suzuki reaction, arylboronic acid, aryl halide, palladium, ligand-free, toluene