Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

doi:10.1016/S1872-2067(11)60355-0

Abstract

Abstract: A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple, effective, and environmentally friendly was shown. Ammonium dihydrogen phosphate (NH₄H₂PO₄) was used as a non-toxic, inexpensive, and easily available catalyst. The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.

Key words: 3,4-dihydropyrimidin-2-(1H)-one, ammonium dihydrogen phosphate, solvent free, condensation

Reza TAYEBEE, Behrooz MALEKI, Malihe GHADAMGAHI. Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones[J]. Chinese Journal of Catalysis, 2012, 33(4): 659-665.

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