Chinese Journal of Catalysis ›› 2014, Vol. 35 ›› Issue (1): 58-65.DOI: 10.1016/S1872-2067(12)60706-2

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H3PW12O40 catalyzed synthesis of benzoxazine and quinazoline in aqueous media

Mahmood Tajbakhsh, Rahman Hosseinzadeh, Parizad Rezaee, Mahgol Tajbakhsh   

  1. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, 47415, Iran
  • Received:2013-07-05 Revised:2013-09-04 Online:2013-12-23 Published:2014-01-17
  • Contact: Mahmood Tajbakhsh

Abstract:

A heteropolyacid efficiently catalyzed the cyclocondensation reaction of 2-aminobenzamide and salicylamide with aldehydes and ketones to afford good yields of benzoxazine and quinazoline ring systems in an aqueous medium. The method gives clean reactions, has simple workup procedure, and uses environment friendly conditions.

Key words: Heteropoly acid, 1,3-Benzoxazine-4-one, 2-Substituted-quinazolin-4(3H)-one, 2-Substituted-2,3-dihydroquinazolin-4(1H)-one