An Efficient Protocol for a Pd(OAc)2-Catalyzed Ligand-Free Suzuki Reaction in Toluene

doi:10.1016/S1872-2067(10)60119-2

Abstract

Abstract: An efficient protocol for a Pd(OAc)₂-catalyzed ligand-free Suzuki reaction of aryl bromides with arylboronic acids in the presence of K₃PO₄·7H₂O in toluene under mild and aerobic conditions afforded cross-coupling products in good to excellent yields. Under the optimized reaction conditions (i.e., 0.5 mmol ArBr, 0.75 mmol ArB(OH)₂, 1 mol% Pd(OAc)₂, 1.0 mmol K₃PO₄·7H₂O, 2 ml toluene), the Suzuki reaction between 4-nitrobromobenzene and phenylboronic acid afforded a 99% isolated yield in 5 min at 75 °C and a TOF of up to 1 188 h^-1.

Key words: Suzuki reaction, arylboronic acid, aryl halide, palladium, ligand-free, toluene

LIU Ning, LIU Chun*, JIN Zilin. An Efficient Protocol for a Pd(OAc)₂-Catalyzed Ligand-Free Suzuki Reaction in Toluene[J]. Chinese Journal of Catalysis, 2010, 31(11): 1316-1320.

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URL: https://www.cjcatal.com/EN/10.1016/S1872-2067(10)60119-2

https://www.cjcatal.com/EN/Y2010/V31/I11/1316

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An Efficient Protocol for a Pd(OAc)₂-Catalyzed Ligand-Free Suzuki Reaction in Toluene

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