Chinese Journal of Catalysis ›› 2015, Vol. 36 ›› Issue (7): 1023-1028.DOI: 10.1016/S1872-2067(15)60846-4

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An efficient green synthesis of dispirohydroquinolines via a diastereoselective one-pot eight-component reaction

Sajjad Salahia, Malek Taher Maghsoodloua, Nourallah Hazeria, Mojtaba Lashkaria, Santiago Garcia-Grandab, Laura Torre-Fernandezb   

  1. a Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran;
    b Department of Physical and Analytical Chemistry, University of Oviedo-CINN, Oviedo, Spain
  • Received:2015-01-25 Revised:2015-03-19 Online:2015-06-12 Published:2015-07-30

Abstract:

The one-pot eight-component reaction between Meldrum's acid, an aromatic aldehyde, and an aryl amine was achieved in the presence of citric acid catalyst. The corresponding dispirohydroquinolines were obtained in good yields with excellent diastereoselectivity. This method is a combination of the Knoevenagel and Michael reactions.

Key words: Eight-component reaction, Dispirohydroquinoline, Meldrum's acid, Citric acid