Catalytic nucleophilic addition of terminal alkynes to α,β-unsaturated-γ-lactams

doi:10.1016/S1872-2067(15)61057-9

Abstract

Abstract:

A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes to α,β-unsaturated-γ-lactams via a cyclic N-acyliminium ion intermediate. This simple reaction proceeds rapidly under mild conditions, and provided a practical approach for the synthesis of a wide range of 5-alkynyl-2-pyrrolidinones in moderate to good yields (45%-76%).

Key words: Carbon-hydrogen addition, Brönsted acid, N-Acyliminium ion, Terminal alkyne, Pyrrolidin-2-one

Maorong Wang, Bao Gao, Hanmin Huang. Catalytic nucleophilic addition of terminal alkynes to α,β-unsaturated-γ-lactams[J]. Chinese Journal of Catalysis, 2016, 37(4): 476-483.

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URL: https://www.cjcatal.com/EN/10.1016/S1872-2067(15)61057-9

https://www.cjcatal.com/EN/Y2016/V37/I4/476

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