催化学报

催化学报 ›› 2011, Vol. 32 ›› Issue (7): 1204-1207.DOI: 10.3724/SP.J.1088.2011.10225

• 研究论文 • 上一篇    下一篇

乙二醇中钯催化无配体的室温 Suzuki 反应

刘春*, 韩娜, 袁浩, 何晓宇, 金子林   

  1. 大连理工大学精细化工国家重点实验室, 辽宁大连 116024
  • 收稿日期:2011-02-20 修回日期:2011-03-16 出版日期:2011-07-18 发布日期:2014-11-28

Pd(OAc)2-Catalyzed Ligand-Free Suzuki Reaction in Ethylene Glycol at Room Temperature

LIU Chun*, HAN Na, YUAN Hao, HE Xiaoyu, JIN Zilin   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, Liaoning, China
  • Received:2011-02-20 Revised:2011-03-16 Online:2011-07-18 Published:2014-11-28

PDF

1151

被引次数

7

摘要： 报道了一种在室温下醋酸钯催化乙二醇中无外加配体的 Suzuki 反应体系. 以 K3PO4.7H2O 为碱, 在该体系中可高效进行芳基溴代物和芳基硼酸的 Suzuki 交叉偶联反应, 具有反应条件温和、无需惰性气体保护等特点. 在 n(ArBr) = 0.5 mmol, n(ArB(OH)2) = 0.75 mmol, x(Pd(OAc)2) = 0.5 mol%, n(K3PO4•7H2O) = 1.0 mmol, v(乙二醇) = 2 ml 的优化条件下, 4-溴苯甲醚和苯硼酸反应 20 min, 分离收率即达 95%.

关键词: Suzuki 反应, 钯, 无配体, 乙二醇, 室温

Abstract: An aerobic and efficient protocol has been developed for the Pd(OAc)2-catalyzed ligand-free Suzuki reaction of aryl bromides with aryl boronic acids in ethylene glycol at room temperature, affording cross-coupling products in good to excellent yields. Under the optimized reaction conditions (i.e., 0.5 mmol ArBr, 0.75 mmol ArB(OH)2, 0.5 mol% Pd(OAc)2, 1.0 mmol K3PO4·7H2O, and 2 ml ethylene glycol), the Suzuki reaction between 4-bromoanisole and phenylboronic acid provided a 95% isolated yield in 20 min.

Key words: Suzuki reaction, palladium, ligand-free, ethylene glycol, room temperature