Chinese Journal of Catalysis ›› 2013, Vol. 34 ›› Issue (9): 1730-1733.DOI: 10.1016/S1872-2067(12)60644-5

• Research papers • Previous Articles     Next Articles

{[K.18-Crown-6]Br3}n:A tribromide catalyst for the catalytic protection of amines and alcohols

Gholamabbas Chehardolia, Mohammad Ali Zolfigolb, Fateme Derakhshanpanahb   

  1. a Department of Medicinal Chemistry, School of Pharmacy, Hamedan University of Medical Sciences, Hamedan 65178, Iran;
    b Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran
  • Received:2013-04-04 Revised:2013-06-19 Online:2013-09-16 Published:2013-08-28

Abstract:

{[K.18-Crown-6]Br3}n, a unique tribromide-type catalyst, was utilized for the N-boc protection of amines and trimethylsilylation (TMS) and tetrahydropyranylation (THP) of alcohols. The method is general for the preparation of N-boc derivatives of aliphatic (acyclic and cyclic) and aromatic, and primary and secondary amines and also various TMS-ethers and THP-ethers. The simple separation of the catalyst from the product is one of the many advantages of this method.

Key words: {[K.18-Crown-6]Br3}n, Trimethylsilylation, Tetrahydropyranylation, Alcohol, Organic tribromide, N-boc protection of amine