催化学报

催化学报 ›› 2011, Vol. 32 ›› Issue (6): 1003-1010.DOI: 10.3724/SP.J.1088.2011.10112

• 研究论文 • 上一篇    下一篇

不同反应体系中 (S)-1-(4-甲氧基)-苯基乙醇的不对称生物合成

汪薇1, 宗敏华1,*, 娄文勇2   

  1. 1仲恺农业工程学院轻工食品学院, 广东广州 510225; 2华南理工大学应用生物催化实验室, 广东广州 510640
  • 收稿日期:2011-01-17 修回日期:2011-02-21 出版日期:2011-06-21 发布日期:2014-10-31

Asymmetric Biosynthesis of (S)-1-(4-Methoxyphenyl)ethanol in Various Reaction Systems

WANG Wei1, ZONG Minhua2,*, LOU Wenyong2   

  1. 1College of Light Industry and Food Science, ZhongKai University of Agriculture and Engineering, Guangzhou 510225, Guangdong, China; 2Laboratory of Applied Biocatalysis, South China University of Technology, Guangzhou 510640, Guangdong, China
  • Received:2011-01-17 Revised:2011-02-21 Online:2011-06-21 Published:2014-10-31

PDF

793

被引次数

13

摘要： 在不同反应体系中, 研究了固定化红酵母细胞催化对甲氧基苯乙酮不对称还原合成 (S)-1-(4-甲氧基)-苯基乙醇的反应. 结果表明, 在含离子液体的混合反应体系和双相反应体系中, 该不对称还原反应的效率得到了不同程度的提高. 此外, 离子液体中阴阳离子类型对该反应的影响较大, 特定阴阳离子间的匹配对固定化红酵母细胞发挥最佳催化效果至关重要.

关键词: 对甲氧基苯乙酮, 1-(4-甲氧基)-苯基乙醇, 离子液体, 催化, 微生物细胞, 不对称生物合成

Abstract: The biocatalytic enantioselective reduction of 4-methoxyacetophenone to (S)-1-(4-methoxyphenyl)ethanol was studied. The efficiency of the reaction was improved to different extents when an ionic liquid-containing co-solvent system and an ionic liquids/bufffer biphasic system were used. The catalytic performance of the biocatalyst depended not only on the types of the anions and cations in the ionic liquids but also on their combination.

Key words: 4-methoxyacetophenone, 1-(4-methoxyphenyl)ethanol, ionic liquid, catalysis, microbial cell, asymmetric biosynthesis