Chinese Journal of Catalysis ›› 2010, Vol. 31 ›› Issue (9): 1098-1102.DOI: 10.1016/S1872-2067(10)60106-4

• Research papers • Previous Articles     Next Articles

Methylsulfonyl-Based Sulfamide-Amine Alcohol as a Ligand for Enantioselective Alkynylation of Aldehydes

JIN Wei, HUANG Yongbo, WAN Boshun*   

  1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China
  • Received:2010-09-30 Online:2010-09-30 Published:2014-01-25

Abstract: Chiral methylsulfonyl-based sulfamide-amine alcohol (SAA) ligands were synthesized from commercially available starting materials in two simple steps. Methylsulfonyl-based SAA ligands catalyzed the asymmetric alkynylation of various aldehydes using alkynylzinc to provide chiral propargyl alcohols with moderate to good enantioselectivity up to 83% ee.

Key words: sulfamide-amine alcohol, enantioselective addition, alkynylation, aldehyde